Research
Our lab focuses on understanding the molecular mechanisms of mutations called gene amplifications and copy number variations (CNVs). Many important biological phenomena, including cancer, infectious diseases, and bioremediation, depend on these mutations to evolve rapidly to their changing environments. Still, the underlying molecular mechanisms remain unclear for all organisms. Our lab aims to unravel these central mysteries along with developing various CNV-related applications.

In order to study gene amplifications and copy number variations, our lab utilizes some of the most genetically tractable organisms: bacteria such as E. coli, Salmonella, and Acinetobacter baylyi. The projects are accessible to undergraduate and Master’s students. Students are trained in important multidisciplinary areas that bridge classical and modern genetics with microbiology, molecular biology, experimental evolution, statistics, and computation.

​Publications

Research Gate

Google Scholar

Dr. Reams’ research team during Summer 2019 (from left to right) back row: Daniel Davis, Ryan Staley, Shyla Difuntorum, Dr. Drew Reams, Eric McPherson, Rola Ghobashy, Agata Koprowka; middle row: Dr. Semarhy Quiñones, Elizabeth Reis, Jennifer Herrmann, Charlotte Difuntorum, Habeeba Awwad, Lamrot Tulu, Cynthia Recendez; front row: Ayesha Shabbir, Kelly Faeth, Constancia Dominguez, Tesa Winters. Not in photo: Katie Bennett and Austin Widdershoven

Current Lab Members:
Semarhy Quiñones (Co-Investigator)
Elizabeth Reis (Masters program)
Katherine Bennett (Masters program)
Tesa Winters (Masters program)
Jennifer Herrmann (Masters program)
Ryan Staley (Masters program)
Rola Ghobashy
Daniel Davis
Lamrot Tulu
Constancia Dominguez
Cynthia Recendez
Agata Koprowska
Ayesha Shabbir
Mario Lopez
Nancy Villanueva
Jennifer Serrano
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Lab Alumni:
Habeeba Awwad, Kelly Faeth, Shyla Difuntorum, Austin Widdershoven, Raylene Olmos, ​Mariela Vega, Stephanie Avalos, Itzel Cardozo, Sam Cabral, Shannon Clayton, Nathalie Villegas, ​Eric McPherson, Cody Lee, Josephine Sami, Abraham Sugay, Renee Avila, Heather "Andy" Geyer, Alejandra Ahumada, Caitlin Harris, Sinai Yoo, Janeé Carter, Gerard LaBlue, Katlyn Lewis, Sophia Romero, Jasmin Suazo, Daniela, Tapia-Acosta, Maggie Cortez, Paul Riling, Rebecca Preto, Kristen DeBacker, Jaime Fuentes, Emily Barentson, Anthony Milani, and Lance "Teo" Courtney

Ayesha Shabbir won 2nd place for her research talk at the Student Research & Creative Activity Spring Symposium held on Monday, March 9 2020.

Daniel (left) and Constancia (right) presented their gene amplification research at the 2020 CSUPERB conference in Santa Clara, CA

Cynthia Recendez presented her research at the NSM Research Symposium in October 2019 and the CSUS Fall Forum in November 2019.

Kelly Faeth presented her research at the CSUS Fall Forum in November 2019.

Lamrot Tulu (left) and Tesa Winters (right) presented their research at the CSUS Fall Forum in November 2019.

Habeeba Awwad (left) and Rola Ghobashy (right) presented their research at the NSM Research Symposium in October 2019.

Daniel Davis presented his research at the NSM Research Symposium in October 2019.

Constancia Dominguez presented her research at the NSM Research Symposium in October 2019.

Sam Cabral presented his gene amplification research at the 2017 Sac State Student Research Symposium

Habeeba (left) and Rola (right) presented their siderophore and gene amplification research at the 2019 California State University Program for Education and Research in Biotechnology (CSUPERB) conference in Orange County, CA

Josephine Sami (left) and Elizabeth Reis (right) resented their gene amplification research at the 2016 California State University Program for Education and Research in Biotechnology (CSUPERB) conference in Orange County, CA

Dr. Reams’ research team during Spring 2017 (from left to right): Jennifer Herrmann (Chemistry major), Dr. Drew Reams (PI), Dr. Semarhy Quiñones-Soto (co-PI), Shannon Clayton (Biology major), Nathalie Villegas (Biology major), Elizabeth Reis (Masters student), and Samuel Cabral (Biology major).